T-cell receptor T-cell therapy treatment process

The potential T-cell receptor (TCR) T-cell therapy treatment journey for patients with solid tumors

Similar to other T-cell therapies, TCR T-cell therapies are administered as a single infusion. The major steps in the process typically include^1,2:

HLA=human leukocyte antigen; mRNA=messenger RNA; PBMC=peripheral blood mononuclear cell.

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Antigen expression in solid tumors

References

1. Tsimberidou AM, Morris KV, Vo HH, et al. T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors. J Hematol Oncol. 2021;14(1):102.
2. He Q, Jiang X, Zhou X, Weng J. Targeting cancers through TCR-peptide/MHC interactions. J Hematol Oncol. 2019;12(1):139.